ABSTRACT
Objective: To investigate the effects of sustained inhalation of sevoflurane on cognitive function and the expression of oxidative stress response proteins such as NADPH oxidase subunits NOX2 and NOX4 in elderly patients undergoing radical surgery for lung cancer
Study Design: An experimental study
Place And Duration Of Study: Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, China, from February 2016 to October 2017
Methodology: Elderly patients who underwent radical surgery for lung cancer were divided into the sevoflurane group and the propofol group, with 52 cases in each group. Sustained inhalation of sevoflurane and propofol was administered to maintain anesthesia in the respective groups. Cognitive function and lung function parameters were compared between the two groups. Serum S100 beta levels and expression of NOX2 and NOX4 proteins in peripheral blood mononuclear cells of the two groups were determined
Results: At 24 hours after surgery, the lung function indices of the sevoflurane group such as FEV1, FVC and VC were higher than those of the propofol group [p<0.001, p=0.008 and p=0.002, respectively]. At the end of the surgery and at 24 hours after surgery, the MMSE scores of the sevoflurane group were higher than the propofol group [all p< levels were lower than the propofol group [p=0.003 and p?0.001]. S100<0.001, respectively]. Levels of NADPH oxidase subunits NOX2 and NOX4 proteins in peripheral blood mononuclear cells of the sevoflurane group were lower than the propofol group [p=0.033, p<0.001, p<0.001and p<0.001, respectively]
Conclusion: Compared with intravenous anesthesia with propofol, general anesthesia with sevoflurane inhalation has little effect on the short-term cognitive function in elderly patients undergoing radical surgery for lung cancer, and can effectively improve lung function. The mechanism may be related to the reduction of the expression of NOX2 and NOX4 proteins
ABSTRACT
OBJECTIVE:To study the stability of Aloe gel under conditions of high and low temperature, high humidity and high light and to predicate its validity duration stored under room temperature. METHODS: The content of Polysaccharide in the gel was determined by phenol-sulfuric acid method. Aloe gel was put under the conditions of high temperature, low temperature, high-relative humidity, and high light to investigate the changes in appearance, pH and content. The expiry term of Aloe gel was predicted by initial average rate method. RESULTS: The content was highly correlated to temperature, but it had little correlation with light and humidity. The validity duration for Aloe gel at room temperature (25 ℃) is expected to be 1 year. CONCLUSION: Aloe gel should be cool-stored under room temperature.